![]() ![]() Morimoto, Bill and Gayle Cook Professor of Biochemistry, Molecular Biology and Cell Biology in Northwestern's Weinberg College of Arts and Sciences, who led the research team. "To find that small molecules reproduce our genetic observations - that both environment and genetics cause a molecular defect in the ability of proteins to function in muscle cells - was not expected," said Richard I. ![]() Whether due to genetic mutation or exposure to small molecules, the neurons become overexcited and fire incorrect signals too rapidly, resulting in proteins in target muscle cells becoming stressed, misfolding and becoming non-functional. Similar results and consequences on protein folding were found to occur upon exposure to the common toxins nicotine and lindane (a pesticide). elegans causes an imbalance in neuronal signaling that results in protein damage in target cells. Now a Northwestern University study reports that a mutation in a transcription factor that controls a neurotransmitter in the nematode C. But that's if the neurotransmitters are getting it right and sending proper signals downstream to muscle cells, neurons or other cells. They initiate events that are critical to a healthy life, giving us the ability to move, to talk, to breathe, to think.
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